FREE USPS Ground Shipping On Any Size Order!*
Have Questions? Call
1.877.465.0844
Mon-Fri 5 A.M.-9 P.M., Sat 6 A.M.-6 P.M. PT
1.877.465.0844
Mon-Fri 5 A.M.-9 P.M., Sat 6 A.M.-6 P.M. PT
E-Tocotrienols Basics
Why we recommend Tocotrienols
Tocotrienols: this may be a new word to you but if you have cardiovascular problems or diabetes in your family, you will want to take a couple of minutes to learn more.
Eight different compounds have been identified in nature as having Vitamin E activity. Four of these are tocopherols and four are tocotrienols (pronounced toe koe tree en awls). Tocopherols are what you find in most Vitamin E supplements. Tocotrienols and tocopherols are similar in structure but have a couple of important differences that puts them into separate subcategories of Vitamin E. Tocopherols are found in highest concentrations in corn, soybean and olive oils. Tocotrienols are found in highest concentrations in palm, rice bran and barley oils.
Scientists have noted that people with higher LDL, lower HDL, higher total cholesterol and higher triglycerides are at greater risk for cardiovascular problems than people with these levels in ideal ranges. Your doctor may have already prescribed a cholesterol-lowering medication.
Studies have reported dramatic changes in these lipid profiles by using tocotrienols. Tocotrienols improve CoQ-10 activity and that helps regulate total cholesterol and also helps shift the ratios of LDL and HDL toward more healthy levels.
The ability to improve CoQ-10 activity has to do with their powerful anti-oxidant properties. This contributes in a significant way to heart health so tocotrienols are described by researchers as cario-protective. Tocotrienols have also been described in these studies as being able to attenuate myocardial ischemia-reperfusion injury (reduced damage from heart attacks), atherosclerosis (build-up of deposits in the arteries) and reduced ventricular arrhythmia. That ventricular arrhythmia is very effective in killing people. Tocotrienols also appear to have a favorable effect on blood pressure.
If that isn’t enough, tocotrienols have been shown to have powerful anti-cancer properties and have help regulate blood sugar levels.
That is all a complicated way of saying that this cost-effective supplement might be able to be incredibly supportive of some vital areas of your health picture including arteries, heart, blood pressure and helps your immune system fight cancer. In fact this is one supplement that you need just a little of. Your body has the capability of producing some on its own but small doses by way supplementation are what you are after. No need to megadose here, just add a little each day.
I have added some key references along with some excerpts of the conclusions. This is for those of you who are having problems with your cholesterol and/or triglycerides and need a little more convincing.
J Biol Chem. 2008 May 23;283(21):14645-53. Epub 2008 Mar 18. Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis. Bentinger M “Tocotrienol epoxides were especially potent in our system; those with one epoxide moiety in the side-chain generally up-regulated CoQ biosynthesis by 200-300%, whereas those with two such moieties also decreased cholesterol synthesis by 50-90%.”
Atherosclerosis. 2002 Mar;161(1):199-207. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Qureshi AA, “Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism.”
Atherosclerosis. 2005 Oct;182(2):367-74. Epub 2005 Apr 20. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Baliarsingh S “In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals the need for more aggressive LDL-lowering therapy. Most of the lipid lowering agents, currently in use in the treatment of dyslipidemia in type 2 diabetics, have a host of side effects. In contrast, dietary tocotrienols are Vitamin E and have effective lipid lowering property in addition to their potent antioxidant activity. In this study, we have investigated the therapeutic impacts of tocotrienols on serum and lipoprotein lipid levels in type 2 diabetic patients.”
Pancreas. 2009 May;38(4):e124-36. d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. Hussein D, “d-delta-Tocotrienol induced concentration-dependent suppression of cell proliferation” (from a cancer study)
Vaccine. 2000 May 8;18(22):2381-93. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Enioutina EY
Mol Nutr Food Res. 2008 Aug;52(8):921-9. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Wu SJ “Tocotrienol-rich fraction (TRF) of palm oil has been shown to possess potent antioxidant, anticancer, and cholesterol lowering activities. In this study, our aim was to examine the effects of TRF on LPS-induced inflammatory response through measuring the production of inflammatory mediators, namely nitric oxide (NO), prostaglandin E(2) (PGE(2)), inducible nitric oxide synthase (iNOS), cytokines (TNF-alpha, IL-4, and IL-8), cyclooxygenase-1 and -2 (COX-1 and COX-2), and nuclear factor-kappaB (NF-kappaB) in human monocytic (THP-1) cells.”
Pharmacol Biochem Behav. 2009 Apr;92(2):251-9. Epub 2008 Dec 24. Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Kuhad A
Eur J Appl Physiol. 2009 Nov;107(5):587-95. Epub 2009 Aug 25. Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats. Lee SP “Taken together, these results suggest that TRF (tocotrienol rich fraction)is able to improve the physiological condition and reduce the exercise-induced oxidative stress in forced swimming rats.”
Ann N Y Acad Sci. 2004 Dec;1031:127-42. Tocotrienol: the natural vitamin E to defend the nervous system? Sen CK “Tocotrienols possess powerful antioxidant, anticancer, and cholesterol-lowering properties.”
Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8. Epub 2007 Dec 14. Cardioprotection with palm oil tocotrienols: comparision of different isomers. Das S “A recent study from our laboratory indicated the cardioprotective ability of the tocotrienol-rich fraction (TRF) from red palm oil. The present study compared cardioprotective abilities of different isomers of tocotrienol against TRF as recently tocotrienol has been found to function as a potent neuroprotective agent against stroke.”
Vitam Horm. 2007;76:419-33. Tocotrienols in cardioprotection. Das S “Tocotrienols, a group of Vitamin E stereoisomers, offer many health benefits including their ability to lower cholesterol levels, and provide anticancer and tumor-suppressive activities. Several recent studies determined the cardioprotective abilities of tocotrienols..”
Arch Pharm Res. 2008 Sep;31(9):1212-7. Epub 2008 Sep 20. Arterial compliance and vitamin E blood levels with a self-emulsifying preparation of tocotrienol rich vitamin E. Rasool AH “tocotrienol vitamin E has potent antioxidant property”
Nutri-West E-Tocotrienols
Tocotrienols: this may be a new word to you but if you have cardiovascular problems or diabetes in your family, you will want to take a couple of minutes to learn more.
Eight different compounds have been identified in nature as having Vitamin E activity. Four of these are tocopherols and four are tocotrienols (pronounced toe koe tree en awls). Tocopherols are what you find in most Vitamin E supplements. Tocotrienols and tocopherols are similar in structure but have a couple of important differences that puts them into separate subcategories of Vitamin E. Tocopherols are found in highest concentrations in corn, soybean and olive oils. Tocotrienols are found in highest concentrations in palm, rice bran and barley oils.
Scientists have noted that people with higher LDL, lower HDL, higher total cholesterol and higher triglycerides are at greater risk for cardiovascular problems than people with these levels in ideal ranges. Your doctor may have already prescribed a cholesterol-lowering medication.
Studies have reported dramatic changes in these lipid profiles by using tocotrienols. Tocotrienols improve CoQ-10 activity and that helps regulate total cholesterol and also helps shift the ratios of LDL and HDL toward more healthy levels.
The ability to improve CoQ-10 activity has to do with their powerful anti-oxidant properties. This contributes in a significant way to heart health so tocotrienols are described by researchers as cario-protective. Tocotrienols have also been described in these studies as being able to attenuate myocardial ischemia-reperfusion injury (reduced damage from heart attacks), atherosclerosis (build-up of deposits in the arteries) and reduced ventricular arrhythmia. That ventricular arrhythmia is very effective in killing people. Tocotrienols also appear to have a favorable effect on blood pressure.
If that isn’t enough, tocotrienols have been shown to have powerful anti-cancer properties and have help regulate blood sugar levels.
That is all a complicated way of saying that this cost-effective supplement might be able to be incredibly supportive of some vital areas of your health picture including arteries, heart, blood pressure and helps your immune system fight cancer. In fact this is one supplement that you need just a little of. Your body has the capability of producing some on its own but small doses by way supplementation are what you are after. No need to megadose here, just add a little each day.
I have added some key references along with some excerpts of the conclusions. This is for those of you who are having problems with your cholesterol and/or triglycerides and need a little more convincing.
J Biol Chem. 2008 May 23;283(21):14645-53. Epub 2008 Mar 18. Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis. Bentinger M “Tocotrienol epoxides were especially potent in our system; those with one epoxide moiety in the side-chain generally up-regulated CoQ biosynthesis by 200-300%, whereas those with two such moieties also decreased cholesterol synthesis by 50-90%.”
Atherosclerosis. 2002 Mar;161(1):199-207. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Qureshi AA, “Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism.”
Atherosclerosis. 2005 Oct;182(2):367-74. Epub 2005 Apr 20. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Baliarsingh S “In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals the need for more aggressive LDL-lowering therapy. Most of the lipid lowering agents, currently in use in the treatment of dyslipidemia in type 2 diabetics, have a host of side effects. In contrast, dietary tocotrienols are Vitamin E and have effective lipid lowering property in addition to their potent antioxidant activity. In this study, we have investigated the therapeutic impacts of tocotrienols on serum and lipoprotein lipid levels in type 2 diabetic patients.”
Pancreas. 2009 May;38(4):e124-36. d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells. Hussein D, “d-delta-Tocotrienol induced concentration-dependent suppression of cell proliferation” (from a cancer study)
Vaccine. 2000 May 8;18(22):2381-93. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants. Enioutina EY
Mol Nutr Food Res. 2008 Aug;52(8):921-9. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Wu SJ “Tocotrienol-rich fraction (TRF) of palm oil has been shown to possess potent antioxidant, anticancer, and cholesterol lowering activities. In this study, our aim was to examine the effects of TRF on LPS-induced inflammatory response through measuring the production of inflammatory mediators, namely nitric oxide (NO), prostaglandin E(2) (PGE(2)), inducible nitric oxide synthase (iNOS), cytokines (TNF-alpha, IL-4, and IL-8), cyclooxygenase-1 and -2 (COX-1 and COX-2), and nuclear factor-kappaB (NF-kappaB) in human monocytic (THP-1) cells.”
Pharmacol Biochem Behav. 2009 Apr;92(2):251-9. Epub 2008 Dec 24. Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Kuhad A
Eur J Appl Physiol. 2009 Nov;107(5):587-95. Epub 2009 Aug 25. Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats. Lee SP “Taken together, these results suggest that TRF (tocotrienol rich fraction)is able to improve the physiological condition and reduce the exercise-induced oxidative stress in forced swimming rats.”
Ann N Y Acad Sci. 2004 Dec;1031:127-42. Tocotrienol: the natural vitamin E to defend the nervous system? Sen CK “Tocotrienols possess powerful antioxidant, anticancer, and cholesterol-lowering properties.”
Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H970-8. Epub 2007 Dec 14. Cardioprotection with palm oil tocotrienols: comparision of different isomers. Das S “A recent study from our laboratory indicated the cardioprotective ability of the tocotrienol-rich fraction (TRF) from red palm oil. The present study compared cardioprotective abilities of different isomers of tocotrienol against TRF as recently tocotrienol has been found to function as a potent neuroprotective agent against stroke.”
Vitam Horm. 2007;76:419-33. Tocotrienols in cardioprotection. Das S “Tocotrienols, a group of Vitamin E stereoisomers, offer many health benefits including their ability to lower cholesterol levels, and provide anticancer and tumor-suppressive activities. Several recent studies determined the cardioprotective abilities of tocotrienols..”
Arch Pharm Res. 2008 Sep;31(9):1212-7. Epub 2008 Sep 20. Arterial compliance and vitamin E blood levels with a self-emulsifying preparation of tocotrienol rich vitamin E. Rasool AH “tocotrienol vitamin E has potent antioxidant property”
Nutri-West E-Tocotrienols
