Some people will need to ease into the use of LifeWave Glutathione Patches. It just depends on your current state of detox. If you have a reaction, it doesn't mean the patches are bad for you. On the contrary a healthy person with a good detox system, you shouldn't notice much of anything. So be ready to take the patch off and try again in a couple of days. We have seen this work with seriously ill people so hang in there.