Klaire Labs SAMe 200 supports membrane function, neurotransmission, liver detoxification, and bone and joint health. SAMe can be synthesized in the body, it is dependent upon the presence of sufficient levels of other nutrients including methionine, folic acid, and vitamin B12. Dietary supplementation of SAMe is an effective way to support optimal levels of this compound. SAMe (S-adenosylmethionine) is a natural compound made in the body from the essential amino acid L-methionine. SAMe donates methyl groups to create other compounds in a process called methylation. Methyl groups are crucial for formation of cell components including proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. Creatine, involved in energy production, and melatonin are also formed from SAMe. The sulfur content of SAMe is used to support synthesis of cartilage, ligaments, tendons, and bones and to form amino acids and peptides such as glutathione, cysteine, and taurine that detoxify foreign substances in the liver. Low levels of SAMe may result in lowered serotonin levels, a brain chemical that supports mood and emotional well-being. SAMe is also required for nerve regeneration. SAMe has been shown in numerous controlled clinical trials to support healthy mood. In numerous human clinical trials, SAMe has demonstrated benefits for joint structure and function comparable or superior to those of other sulfur-containing nutrients such as glucosamine sulfate, chondroitin sulfate, and MSM. Research suggests that the mechanism of action behind this benefit may be due to this compound's support of cartilage formation. Recommended Use: 1 tablet, 1 to 6 times daily on an empty stomach or as directed by a healthcare professional.
Other Ingredients: Cellulose, mannitol, sodium starch glycolate, silicon dioxide, glyceryl behenate, magnesium stearate, enteric coating (methacrylate copolymers), titanium dioxide, magnesium silicate, triethylcitrate, riboflavin, glycero palmitostearate, and medium chain triglycerides. Caution: Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, should consult their healthcare professional before using this product. Individuals with bipolar disorder or manic depression should not take SAMe unless under medical supervision.