I was recently diagnosed with VA after thinking I had a bladder infection - it was awful - was prescribed antibiotics, took them for two weeks, with no relief. My doctor thought it might be low estrogen (I take oral Estrace twice a day), and was prescribed vaginal estrogen cream. It gave me the worst irritation. I researched online and found that these hydration cubes are used by many women with the same condition, but instead of rubbing them into the skin, they use them vaginally. Because I've always been extremely sensitive to lubricants or anything used in that area, I was concerned that these might irritate me. But they do not - they do exactly what they're supposed to do. I used one a night for two weeks; then backed down to one every other night; and now I use one every third night. I no longer have the urinary discomfort, nor the pain/irritation with sex. I hope they never stop making these.