As stated on the product description page, Avipaxin is a NeuroScience product designed to help reduce general inflammation that can be seen by an improved cytokine profile. Avipaxin can also improve neurotransmitter balance because a healthy balance depends on a healthy general cytokine balance and reduced general inflammation. How does that happen you say? The researchers at NeuroScience chose three different brain protective components and combined them in specific ratios to give the desired effects. The key ingredients are: L-alpha GPC, Acetyl-L-Carnitine and Huperizine A.
L-Alpha Glycerylphosphorylcholine (Alpha GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor and is being explored as a possible treatment of Alzheimer's disease. Some have also used it as a dietary supplement to support memory and cognition.
Alpha GPC rapidly delivers choline to the brain across the blood-brain barrier. It is precursor to the excitatory neurotransmitter acetylcholine.
Acetyl-L-carnitine has been used for some time for a variety of mental disorders including: Alzheimer's disease, age-related memory loss, late-life depression, thinking problems related to alcoholism, and thinking problems related to Lyme disease. Some have also found it useful in cases of Down syndrome, poor circulation in the brain, cataracts, nerve pain due to diabetes, nerve pain and facial paralysis.
Some men find acetyl-L-carnitine useful to help treat infertility, symptoms of "male menopause" (low testosterone levels due to aging), and a disease of the penis called Peyronie's disease.
The body can convert L-carnitine to acetyl-L-carnitine and vice versa. But, no one knows whether the effects of acetyl-L-carnitine are from the chemical itself, from the L-carnitine it can make, or from some other chemical made along the way. For now, don't substitute one form of carnitine for another. For now it is good enough to state that acetyl-L-carnitine helps the body produce energy. It is important for heart and brain function, muscle movement, and many other body processes.
Huperzine A is an acetylcholinesterase inhibitor, which has a mechanism of action similar to donepezil, rivastigmine, and galantamine. A pro-drug form of Huperzine A (ZT-1) is under development as a treatment for Alzheimer's disease. In the US, Huperzine A is sold as a dietary supplement for memory support. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Clinical trials in China have shown it to be effective in the treatment of Alzheimer's disease and memory improvement in students. Huperzine A is also a NMDA receptor antagonist which protects the brain against glutamate induced damage, and it appears to increase nerve growth factor levels in rats.