Cardiovascular Research Annatto Tocotrienols contains gamma tocotrienols and delta tocotrienols obtained from pure annatto plants of the rainforests to support nutritional requirements of the body. Numerous studies over 20 years indicate that tocotrienols show excellent support for cardiovascular protection and heart health. Tocotrienols are also being studied for effects on bone health, blood sugar metabolism, brain health. Tocotrienols offer a safe and effective way to support healthy cholesterol, while simultaneously protecting your arteries. The vitamin E family consists of four tocotrienols and four tocopherols. D alpha tocopherol is the commonly understood form of vitamin E and has been extensively researched and has its own value to human health. The difference between tocotrienols and tocopherols is the "tail" on the vitamin E molecule. Tocopherols have a long saturated tail. Tocotrienols have a short unsaturated tail. The unique structure of tocotrienols enables them to do many things that tocopherols cannot do. This includes easier access to cells, better antioxidant function in cells, a better ability to move around in cells, and the activation of a wide variety of gene signals including cholesterol regulation. Recommended usage: As a dietary supplement, take one (1) softgel daily with an evening meal, or as directed by your healthcare professional.