Pure Encapsulations BenfoMax
helps maintain healthy advanced glycation end (AGE) activity to support vascular, nerve, retinal and kidney cellular health. May also support retinal function as well as nerve comfort. Recommended Use:
1 capsule, 1-3 times daily with meals or as directed by a healthcare professional.
- Helps maintain healthy glucose metabolism
- Promotes vascular, retinal, kidney and neuronal health
- Made with hypoallergenic, vegan ingredients
What Is It? Benfotiamine, S-benzoylthiamine-O-monophosphate, is a fat soluble vitamin B1 (thiamine) derivative that exhibits enhanced bioavailability and bioactivity. It is found naturally in small amounts in vegetables from the Allium genus, including garlic, onions, and leeks. Experimental pharmacokinetic data indicates that benfotiamine has a greater absorption rate and duration of activity compared to water-soluble thiamine, including thiamine HCl. It has also been found to be better tolerated than thiamine. Research suggests that benfotiamine maintains healthy advanced glycation end (AGE) product activity to support vascular, nerve, retinal and kidney cellular health.
Uses For BenfoMax Healthy Advanced Glycation End Product Activity:
Benfotiamine provides enhanced support for healthy thiamine levels in the body, which in turn promotes optimal production of the enzyme thiamine pyrophosphate, or TPP. This is key to the significance of benfotiamine, since TPP plays a role in maintaining healthy advanced glycation end product, or AGE, activity. TPP promotes healthy transketolase activity, an important enzyme in glucose metabolism, to support vascular health through three biochemical pathways. This is believed to be particularly supportive for maintaining healthy vascular, retinal, nerve and kidney function in some individuals. In a randomized cross-over trial, benfotiamine supported healthy flow mediated dilation and endothelial function in response to a heat-treated meal. In another randomized controlled study, benfotiamine supported healthy nerve conduction velocity and nerve comfort. Research suggests it may also promote healthy renal glomeruli and retinal function, in part by moderating protein kinase C enzyme activity, AGE production and protein glycation, and maintaining healthy activity of the genomic regulator NF-?B to support cytokine balance.